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AD-35 hydrochloride
CAS No. 1531586-62-5
AD-35 hydrochloride ( AD35 hydrochloride;AD 35 hydrochloride )
Catalog No. M12149 CAS No. 1531586-62-5
A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameAD-35 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
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DescriptionA donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.
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SynonymsAD35 hydrochloride;AD 35 hydrochloride
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PathwayMetabolic Enzyme/Protease
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TargetAChE
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RecptorAChE
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Research Area——
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Indication——
Chemical Information
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CAS Number1531586-62-5
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Formula Weight441.96
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Molecular FormulaC24H28ClN3O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILES——
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Chemical Name6'-(2-(1-(pyridin-2-ylmethyl)piperidin-4-yl)ethyl)spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6'H)-one hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li L, et al. J Alzheimers Dis. 2017;56(4):1403-1417.
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