AD-35 hydrochloride ( AD35 hydrochloride;AD 35 hydrochloride )

Catalog No. M12149 CAS No. 1531586-62-5

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Product Name

AD-35 hydrochloride
Note

Research use only, not for human use.
Brief Description

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
Description

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.
Synonyms

AD35 hydrochloride;AD 35 hydrochloride
Pathway

Metabolic Enzyme/Protease
Target

AChE
Recptor

AChE
Research Area

——
Indication

——

CAS Number

1531586-62-5
Formula Weight

441.96
Molecular Formula

C24H28ClN3O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

——
Chemical Name

6'-(2-(1-(pyridin-2-ylmethyl)piperidin-4-yl)ethyl)spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6'H)-one hydrochloride

1. Li L, et al. J Alzheimers Dis. 2017;56(4):1403-1417.

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